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Transdermal application of naturally occurring steroid hormones. Historically, researchers went so far as to categorically state that AAS are without any evidence upon muscle going so far as to argue that there is saturation of the androgen receptor with eugonadal levels of testosterone. Similarities include a characteristic withdrawal syndrome, self-administration by animals as just discussed, continued use despite adverse effects, maladaptive behavioral patterns surrounding use, and comorbid abuse of other substances, as illustrated by the case. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid.

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